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Hormone Therapy in Post-menopausal Women
Hormone therapy is the most effective method of treating post-menopausal vasomotor symptoms. Hot flashes and night sweats occur in about 70% of middle-aged women and can persist for ten years, or even longer, after menopause. Disturbing vasomotor symptoms have significant negative effects on sleep, daily activities, and quality of life. Hot flashes can also often be accompanied by cognitive and mood problems. Although lifestyle changes and non-hormonal treatment options are available; women who complain of frequent and severe vasomotor symptoms benefit greatly from hormone therapy.
Hormone therapy in menopause has positive effects on bone mineral density and the urogenital system; reduces the risk of fractures, alleviates vaginal atrophic changes and symptoms known as the genitourinary syndrome of menopause. If the vasomotor symptoms are not too severe, alternative treatment methods to systemic hormone therapy should be preferred for the risk of fractures and the treatment of genitourinary symptoms. Medications containing very low estrogens with minimal systemic absorption and risk, placed directly in the vagina, effectively reduce the problems and symptoms associated with sexual life that reduce the quality of life, observed in the genitourinary syndrome of menopause.